Highly targeted spatiotemporal interventions against cholera epidemics, 2000–19: a scoping review

Globally, cholera epidemics continue to challenge disease control. Although mass campaigns covering large populations are commonly used control cholera, spatial targeting of case households and their radius is emerging as a potentially efficient strategy. We did Scoping Review investigate the effectiveness interventions delivered through case-area targeted intervention, its optimal spatiotemporal scale, in reducing transmission. 53 articles were retrieved. found that antibiotic chemoprophylaxis, point-of-use water treatment, hygiene promotion can rapidly reduce household transmission, single-dose vaccination extend duration protection within households. Evidence supports high-risk zone 100 m around households, for 7 days. Two evaluations separately showed reductions transmission when size clusters radii. intervention shows promise outbreak control, it critically dependent on early detection capacity requires prospective evaluation packages.